The Defense Advanced Research Projects Agency (DARPA) has announced the creation of a new Biological Technologies Office to explore the intersection of biology and the physical sciences. The BTO goals are to “harness the power of biological systems by applying the rigorous tools of engineering and related disciplines, and to design next-generation technologies that are inspired by insights gained from the life sciences.” The initial BTO portfolio includes programs transferred from the Defense Sciences and Microsystems Technology Offices, but will also include new opportunities.